Acne vulgaris is a multi-factorial dermatological disorder affecting the pilosebaceous follicle characterized by open and/or closed comedones, papules, pustules, nodules and scars. It primarily affects children and adolescents. Available anti-acne drugs are associated with side effects; antibiotic resistance has been increasing in prevalence within the dermatologic setting. In the present study, an attempt has been made to formulate Aloe emodin gel with carbopol 940 as a gelling agent with good anti-acne potential. Aloe-emodin was semi-synthetically prepared from aloin which was previously isolated from Aloe vera (Liliaceae). Obtained compound was then characterized by means of spectral analysis. Antibacterial potential of aloe-emodin gels against P. acnes and S. aureus was determined by agar-well diffusion method which showed good antibacterial activity (Zone of inhibition < 10 mm). Anti-inflammatory activity was determined by carrageenan induced paw edema.
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